Interneurons Differentially Contribute to Spontaneous Network Activity in the Developing Hippocampus Dependent on Their Embryonic Lineage
نویسندگان
چکیده
منابع مشابه
Bidirectional global spontaneous network activity precedes the canonical unidirectional circuit organization in the developing hippocampus
Spontaneous network activity is believed to sculpt developing neural circuits. Spontaneous giant depolarizing potentials (GDPs) were first identified with single-cell recordings from rat CA3 pyramidal neurons, but here we identify and characterize a large-scale spontaneous network activity we term global network activation (GNA) in the developing mouse hippocampal slices, which is measured macr...
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Profound activity-dependent synaptic facilitation at hippocampal mossy fiber synapses is a unique and functionally important property. Although presynaptic ionotropic receptors, such as kainate receptors, contribute partially to the facilitation in the hippocampus, the precise mechanisms of presynaptic regulation by endogenous neurotransmitters remain unclear. In this study, we report that axon...
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viii 1 Review of the literature 1 1.2 Development of hippocampal network 2 1.3 Properties of kainate receptors 5 1.3.1 Structure 5 1.3.3 Pharmacology 10 1.3.2 Signaling 8 1.4 Kainate receptors in immature hippocampus 12 1.4.1 Expression 12 1.4.2 Functions 14 1.4.3 Role in network activity 18 1.5 Ethanol and the developing hippocampus 21 2 Aims 24 3 Materials and methods 25 3.1 Preparation of ac...
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اندیشمندان و صاحب نظران علوم اجتماعی بر این باورند که مرحله تازه ای در تاریخ جوامع بشری اغاز شده است. ویژگیهای این جامعه نو را می توان پدیده هایی از جمله اقتصاد اطلاعاتی جهانی ، هندسه متغیر شبکه ای، فرهنگ مجاز واقعی ، توسعه حیرت انگیز فناوری های دیجیتال، خدمات پیوسته و نیز فشردگی زمان و مکان برشمرد. از سوی دیگر قدرت به عنوان موضوع اصلی علم سیاست جایگاه مهمی در روابط انسانی دارد، قدرت و بازتولید...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2016
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4000-15.2016